(4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

Base Information

Chemical Name:(4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one
CAS No.:785790-12-7
Molecular Formula:C₁₇H₂₂N₄O₄
Molecular Weight:346.386
Hs Code.:

Synonyms:(4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

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Chemical Property of (4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

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Technology Process of (4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

There total 10 articles about (4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 624738-97-2
(3R,5E,αR)-methyl 3-(N-allyl-N-α-methylbenzylamino)hept-5-enoate

: 785790-12-7
(4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / RhCl(PPh₃)3 / acetonitrile; H₂O / 2 h / Heating

2: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 17 h / 20 °C

3: I₂ / CH₂Cl₂ / 4 h / 0 °C

4: aq. NaN₃ / dimethylformamide / 5 h / 110 °C

With dmap; sodium azide; iodine; triethylamine; RhCl(PPh₃)3; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b404962d

Reference yield:

: 624739-02-2
(4R,6R,1'S,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-iodoethyl)-1,3-oxazinan-2-one

: 785790-12-7
(4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 110 ℃; for 5h;
DOI:10.1039/b305740b

Reference yield:

: 18261-30-8,32793-92-3,32793-93-4,40415-88-1,41792-07-8
(E,E)-methyl heptan-2,5-dieneoate

: 785790-12-7
(4R,6R,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-azidoethyl)-1,3-oxazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / tetrahydrofuran / 2 h / -78 °C

2: 97 percent / Wilkinson's catalyst / acetonitrile; H₂O / 2 h / Heating

3: 88 percent / 96 h

4: 77 percent / I₂ / CH₂Cl₂ / 3 h / 0 °C

5: aq. NaN₃ / dimethylformamide / 5 h / 110 °C

With sodium azide; iodine; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b305740b