(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate
CAS No.:141714-15-0
Molecular Formula:C₂₈H₃₂N₂O₅
Molecular Weight:476.572
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

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Chemical Property of (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

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Technology Process of (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

There total 5 articles about (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 3844-54-0
L-2-aminohexanoic acid-methyl ester hydrochloride

: 65365-15-3,96402-43-6
2S-2-benzyloxycarbonylamino-2-(naphth-1-yl)methyl-acetic acid

: 141714-15-0
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; at -5 ℃; for 3h;
DOI:10.1248/cpb.40.364

Reference yield: 65.0%

: 21754-55-2
L-norleucine methyl ester

: 65365-15-3,96402-43-6
2S-2-benzyloxycarbonylamino-2-(naphth-1-yl)methyl-acetic acid

: 141714-15-0
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

Guidance literature:: 2S-2-benzyloxycarbonylamino-2-(naphth-1-yl)methyl-acetic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

L-norleucine methyl ester; With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 55516-54-6,68798-79-8,7758-42-1
L-1-naphthylalanine

: 141714-15-0
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(naphthalen-1-yl)propanamido)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 1 N aq. NaOH / 1.67 h / 0 °C

2: 84.5 percent / N-methylmorpholine, HOBT, DCC / 3 h / -5 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
DOI:10.1248/cpb.40.364