3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

Base Information

Chemical Name:3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester
CAS No.:1239278-74-0
Molecular Formula:C₁₈H₂₅NO₇S
Molecular Weight:399.465
Hs Code.:

Synonyms:3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

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Chemical Property of 3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

Chemical Property:

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Technology Process of 3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

There total 4 articles about 3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1239278-73-9
3-cyclopropylmethoxy-4-methanesulfonylaminobenzoic acid methyl ester

: 1239278-74-0
3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm401549m

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1239278-74-0
3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 50 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / methanol; water; ethyl acetate / 5 h / 1034.32 Torr

2.2: 2 h

3.1: pyridine / 18 h / 20 °C / Inert atmosphere

4.1: dmap / dichloromethane / 1 h / 20 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium iodide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm401549m

Reference yield:

: 1239278-72-8
methyl 3-(cyclopropylmethoxy)-4-nitrobenzoate

: 1239278-74-0
3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol; water; ethyl acetate / 5 h / 1034.32 Torr

1.2: 2 h

2.1: pyridine / 18 h / 20 °C / Inert atmosphere

3.1: dmap / dichloromethane / 1 h / 20 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm401549m