N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

Base Information

Chemical Name:N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine
CAS No.:148032-17-1
Molecular Formula:C₂₅H₃₁NO₃S
Molecular Weight:425.592
Hs Code.:

Synonyms:N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

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Chemical Property of N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

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Technology Process of N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

There total 7 articles about N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 148032-16-0
(S)-2-[(2-tert-Butylsulfanylmethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-phenyl-propionic acid methyl ester

: 148032-17-1
N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

Guidance literature:: With lithium hydroxide; In methanol;
DOI:10.1016/0960-894X(96)00367-8

Reference yield: 72.0%

: 5619-07-8
methyl 2-amino-3-phenylpropanoate hydrochloride

: 148032-07-9
2-carboxy-2-(t-butyl)thiomethyl-1,2,3,4-tetrahydronaphthalene

: 148032-17-1
N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 83516-16-9
chloromethyl tert-butyl sulfide

: 148032-17-1
N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: ZnBr₂ / CH₂Cl₂ / 0.75 h

2: 100 percent / LiOH / methanol / 18 h / Heating

3: 1.) oxalyl chloride, 2.) Et₃N / 2.) CH₂Cl₂

4: 97 percent / LiOH / methanol

With lithium hydroxide; oxalyl dichloride; triethylamine; zinc dibromide; In methanol; dichloromethane;
DOI:10.1016/0960-894X(96)00367-8