(3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Base Information

Chemical Name:(3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS No.:1353050-17-5
Molecular Formula:C₃₉H₄₅FN₄O₁₁
Molecular Weight:764.805
Hs Code.:

Synonyms:(3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Suppliers and Price of (3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

There total 7 articles about (3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1353049-95-2
C₅₁H₇₁FN₄O₁₂Si₂

: 1353050-17-5
(3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield:

: 134523-03-8
lipitor

: 1353050-17-5
(3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 72 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

3: dimedone / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 3 h

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 24 h / 0 - 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; dimedone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1353049-83-8
allyl 2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

: 1353050-17-5
(3R,5R)-((S)-5,6-bis (nitrooxy)hexyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dimedone / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 3 h

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 24 h / 0 - 20 °C

With dmap; tetrabutyl ammonium fluoride; dimedone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane;