1-Benzoyl-4-ethynylpiperidine

Base Information

Chemical Name:1-Benzoyl-4-ethynylpiperidine
CAS No.:943755-84-8
Molecular Formula:C₁₄H₁₅NO
Molecular Weight:213.279
Hs Code.:

Synonyms:1-Benzoyl-4-ethynylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzoyl-4-ethynylpiperidine

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Technology Process of 1-Benzoyl-4-ethynylpiperidine

There total 3 articles about 1-Benzoyl-4-ethynylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 120014-29-1
1-benzoyl-piperidine-4-carboxaldehyde

: 943755-84-8
1-Benzoyl-4-ethynylpiperidine

Guidance literature:: With potassium carbonate; In methanol; for 4.16667h;

Reference yield: 65.0%

: 4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl 1-benzoylpiperidine-4-carboxylate

: 4301-14-8
acetylenemagnesium bromide

: 943755-84-8
1-Benzoyl-4-ethynylpiperidine

Guidance literature:: ethynyl-magnesium bromide; With NiCl₂·6H₂O; 4,4'-Dimethoxy-2,2'-bipyridin; lithium chloride; anhydrous zinc chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl 1-benzoylpiperidine-4-carboxylate; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/acs.joc.2c00380

Reference yield:

: 5274-99-7
1-benzoylisonipecotic acid

: 943755-84-8
1-Benzoyl-4-ethynylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; diisopropyl-carbodiimide / dichloromethane / 17 h / 20 °C

2.1: anhydrous zinc chloride; NiCl₂·6H₂O; 4,4'-Dimethoxy-2,2'-bipyridin; lithium chloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 15 h / 20 °C / Inert atmosphere

With dmap; NiCl₂·6H₂O; 4,4'-Dimethoxy-2,2'-bipyridin; lithium chloride; anhydrous zinc chloride; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.2c00380