tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

Base Information

Chemical Name:tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate
CAS No.:480451-98-7
Molecular Formula:C₂₁H₃₀ClN₅O₅
Molecular Weight:467.953
Hs Code.:

Synonyms:tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

There total 10 articles about tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 552850-73-4
2-((5-chloropyridin-2-yl)amino)-2-oxoacetic acid

: C₂H₂O₄*C₁₄H₂₇N₃O₃

: 480451-98-7
tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

Guidance literature:: With triethylamine; In ethanol; at 80 ℃; for 10h;

Reference yield:

: 365997-31-5
(1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester

: 480451-98-7
tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium hydroxide / ethanol / 24 h / 40 - 45 °C

1.2: 2 h / 20 - 25 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 25 °C

3.1: sodium azide / N,N-dimethyl-formamide / 24 h / 65 - 75 °C

4.1: lithium hydroxide monohydrate / dichloromethane; water; tetrahydrofuran / 24 h / 25 - 30 °C

4.2: 24 h / 35 - 45 °C

5.1: palladium on activated charcoal; ammonium formate / ethanol / 4 h

5.2: 3 h / 25 - 30 °C

6.1: triethylamine / ethanol / 10 h / 80 °C

With ammonium hydroxide; sodium azide; lithium hydroxide monohydrate; palladium on activated charcoal; ammonium formate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 480451-97-6
Tert-butyl {(1R,2R,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate

: 480451-98-7
tert-Butyl (1R,2R,5S)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexyl-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; ammonium formate / ethanol / 4 h

1.2: 3 h / 25 - 30 °C

2.1: triethylamine / ethanol / 10 h / 80 °C

With palladium on activated charcoal; ammonium formate; triethylamine; In ethanol;