(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Base Information

Chemical Name:(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234620-02-0
Molecular Formula:C₂₅H₂₀F₃N₇
Molecular Weight:475.476
Hs Code.:

(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Synonyms:(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

There total 3 articles about (7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1234619-76-1
Benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}(cyclopropylmethyl)carbamate

: 1234620-02-0
(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.75h; under 760.051 Torr;

Reference yield:

: 1234619-70-5
benzyl {(7R)-6-cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

: 1234620-02-0
(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 12 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1.75 h / 20 °C / 760.05 Torr

With 18-crown-6 ether; hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1234737-79-1
(7R)-2-amino-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1234620-02-0
(7R)-7-(4-Cyanophenyl)-2-[(cyclopropylmethyl)amino]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 12 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 12 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 1.75 h / 20 °C / 760.05 Torr

With pyridine; 18-crown-6 ether; hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;