6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

Base Information

Chemical Name:6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one
CAS No.:1026715-22-9
Molecular Formula:C₂₃H₂₉ClN₂O₂
Molecular Weight:400.948
Hs Code.:

Synonyms:6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

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Chemical Property of 6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

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Technology Process of 6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

There total 7 articles about 6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 171285-70-4
(+/-)-7-chloro-8-methoxy-3-<6-(N-carbobenzoxyamino)hexanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 1026715-22-9
6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; for 0.5h; Ambient temperature;
DOI:10.1021/jm00021a018

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 1026715-22-9
6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / tetrahydrofuran / 18 h / Heating

2: 95 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

3: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

4: 79 percent / ISi(Me)3 / acetonitrile / 0.5 h / Ambient temperature

With methanesulfonic acid; trimethylsilyl iodide; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00021a018

Reference yield:

: 1947-00-8
6-(benzyloxycarbonylamino)hexanoic acid

: 1026715-22-9
6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

2: 79 percent / ISi(Me)3 / acetonitrile / 0.5 h / Ambient temperature

With trimethylsilyl iodide; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1021/jm00021a018