1-cyclohexyl-5-acetyltetrazole

Base Information

• Chemical Name: 1-cyclohexyl-5-acetyltetrazole
• CAS No.: 108630-79-1
• Molecular Formula: C₉H₁₄N₄O
• Molecular Weight: 194.236
• Mol file: 108630-79-1.mol

Synonyms:1-cyclohexyl-5-acetyltetrazole

Chemical Property of 1-cyclohexyl-5-acetyltetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclohexyl-5-acetyltetrazole

There total 5 articles about 1-cyclohexyl-5-acetyltetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Acetyl cyanide (631-57-2) + cyclohexyl azide (19573-22-9) → 1-cyclohexyl-5-acetyltetrazole (108630-79-1)

Guidance literature:

In acetonitrile; at 80 ℃; for 8h; under 7500600 Torr;

DOI:10.1007/BF00957087

Reference yield:

1-(1-cyclohexyl-1H-tetrazol-5-yl)-ethanol (37468-99-8) → 1-cyclohexyl-5-acetyltetrazole (108630-79-1)

Guidance literature:

With potassium dichromate; sulfuric acid;

DOI:10.1021/jo50012a006

Reference yield:

5-(1-bromo-ethyl)-1-cyclohexyl-1H-tetrazole (875236-73-0) → 1-cyclohexyl-5-acetyltetrazole (108630-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid

2: aqueous methanol.NaOH

3: K₂cr2O₇; aqueous H₂SO₄

With potassium dichromate; sodium hydroxide; sulfuric acid; acetic acid;

DOI:10.1021/jo50012a006

upstream raw materials:

1-(1-cyclohexyl-1H-tetrazol-5-yl)-ethanol

Acetyl cyanide

cyclohexyl azide

5-(1-bromo-ethyl)-1-cyclohexyl-1H-tetrazole

Refernces

• 1、 Zavarzin, I. V.,Zhulin, V. M.,Yarovenko, V. N.,Krayushkin, M. M.. "SYNTHESIS OF 5-KETOTETRAZOLES UNDER HIGH PRESSURE". . p. 1027 - 1029. Retrieved 2007/10/02.