631-57-2Relevant academic research and scientific papers
CH STRETCHING FREQUENCES AND BOND STRENGTHS, AND METHYL GROUP GEOMETRY IN CH3CXO COMPOUNDS ( X = H, Me, F, Cl, Br, I, CN, OMe) AND CH3CH2CN
McKean, D. C.,Torto, I.
, p. 51 - 60 (1982)
Infrared spectra in the CH stretching region are reported for CHD2CXO and CH3CXO compounds, where X = F, Cl, Br, I, CN, OMe, and for CHD2CD2CN and CD3CHDCN.In all the carbonyl compounds except the iodide the two out-of-plane CH bonds in the methyl group are significantly weaker than the in-plane one.Differences in CH bond length of up to 0.006 Angstroem are predicted, which are considered to be more reliable than the available microwave data.The separations of νasCH3 and νCHD2 frequencies are compatible with a strong angular asymmetry (HsCHa HaCHa) in the acetyl compounds.The gauche and trans effects of halogen on νisCH are similar, but larger, than those in alkyl halides.In ethyl cyanide, the methyl CH bonds are identical in strength.The α and β substituent effects from the CN group fall into no simple pattern.
Novel synthesis method of alpha-carbonyl acid ester
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Paragraph 0016; 0050; 0053, (2020/07/21)
The invention discloses a novel synthesis method of alpha-carbonyl acid ester. The method comprises the following steps: carrying out chlorination reaction on an alpha-methylene-containing nitrile compound and chlorine to obtain dichloronitrile, reacting the dichloronitrile product in a sulfuric acid and water system to obtain formyl cyanide, then acquiring an imino sulfate compound in the same reaction system, and finally performing esterification to obtain the target product. The adopted reaction raw materials are wide in sources and low in price, highly toxic solid sodium cyanide can be prevented from being used in the prior art, the method is environmentally friendly, and the method is easy to operate, mild in condition and easy to industrialize.
N-Heterocyclic Carbene-Catalysed Direct Synthesis of Cyano Esters via Cyanation-Esterification Reaction of α-Keto Esters
Zhang, Jie,Wang, Ying,Du, Guangfen,Gu, Cheng-Zhi,Dai, Bin
, p. 1211 - 1215 (2015/11/02)
The cyanation-esterification reaction of α-keto esters catalysed by N-heterocyclic carbenes (NHCs) is developed. Under the catalysis of 10 mol% 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, aromatic and aliphatic α-keto esters reacted with ethyl cyanoformate or acetyl cyanide to produce the corresponding cyano esters with a tetrasubstituted carbon center in high yields.
ZnI2-catalyzed cyanation of acyl chlorides with TMS-CN: An interesting role of iodine
Zeng, Wei,Yang, Jingya,Meng, Bo,Zhang, Bo,Jiang, Mingzhe,Chen, Fu-Xue
body text, p. 637 - 641 (2010/06/15)
Both aliphatic and aromatic acyl cyanides have been synthesized with TMSCN and acyl chloride with ZnI2 (0.5 mol%). However the in situ generated I2 is proposed accounting for the formation of by-product O-TMS enolate at high catalyst loading rather than 0.5 mol%. Asymmetric reduction of benzoyl cyanide with borane has been explored in 82% yield and 24% ee.
Method for synthesizing sucrose-6-acetic ester
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Page/Page column 1; 2, (2008/12/04)
The present invention discloses a method of synthesizing sucrose-6-acetic ester, comprising the following steps: adding sucrose into a polar aprotic solvent, and stirring the solvent to dissolve it, then generate a suspension solution of sucrose; adding a acetylation agent acetylnitrile into said suspension solution and stirring the solution; adding water into the aforesaid reaction solution, and then concentrating it to generate a concentrated product; adding a crystalline solvent into the concentrated product, stirring to dissolve it, and depositing for crystallization, then filtering and drying it to get a product of sucrose-6-acetic ester. The benefit of the present invention is that the method of synthesizing sucrose-6-acetic ester has simple operation, mild reaction condition, high selectivity, high yield, and is suitable for industrial production.
A novel heterogeneous synthesis of acyl cyanides catalyzed by PEG400 and zinc iodide
Cao, Yu-Qing,Du, Yun-Fei,Chen, Bao-Hua,Li, Ji-Tai
, p. 2951 - 2957 (2007/10/03)
Aroyl cyanides were readily synthesized in moderate yields by the cyanation of aroyl chlorides with dry powdered potassium cyanide under the catalysis of PEG400 and zinc iodide in dichloromethane at room temperature. A preliminary study on the one-pot preparation of acetyl cyanide was also reported.
Unsaturated ozonides from the ozonolysis of cyclodienes in the presence of carbonyl compounds
Park, Shin Hee,Lee, Joo Yeon,Huh, Tae Sung
, p. 3083 - 3087 (2007/10/03)
Treatment of the conjugated C5- to C8-cyclodienes (5a-5b) with one molar equivalent of ozone in dichloromethane in the presence of added carbonyl compounds (3) resulted almost exclusively in monoozonolysis reactions to give the corre
Flash vacuum pyrolysis of 3-oxo-2-arylhydrazonopropanals and related derivatives
Ibrahim, Yehia A,Kaul, Kamini,Al-Awadi, Nouria A
, p. 10171 - 10176 (2007/10/03)
Flash vacuum pyrolysis (FVP) of 3-oxo-2-arylhydrazonopropanals at 500°C and 0.02 Torr yielded the corresponding derivatives of anilines, N-formylanilines, N-benzoylanilines and benzoylnitriles. Similar FVP of phenylhydrazonomalononitrile, phenylhydrazonoa
Reaction of stabilised phosphorus ylides with nitrogen dioxide
Aitken, R. Alan,Karodia, Nazira
, p. 251 - 254 (2007/10/03)
The reaction of the stabilised ylides 14-23 with an excess of NO2 in CH2Cl2 at room temperature gives different results depending on the structure of the starting ylide. The monacyl ylides 14-16 give the corresponding α-oxo nitriles 4 together with Ph3PO · HNO3 (24) which has been fully characterised for the first time. Under the same conditions, the ylide 18 gives 2,4-dinitrobenzonitrile (26), Ph3PO, and benzoic acid. The other ylides examined all give 24 together with a variety of other products.
CYANO SUBSTITUTED OZONIDES: PREPARATION, PROPERTIES AND UNUSUAL BEHAVIOR TOWARDS REDUCING AGENTS
Griesbaum, Karl,Huh, Tae-Seong,Gutsche, Sven-Hendrik
, p. 3299 - 3300 (2007/10/02)
Ozonolyses of 2-cyanopropene (1a) and of 2,4-dicyano-1-butene (1b) gave the corresponding ozonides 3-cyano-3-methyl- (2a) and 3-cyano-3-(2-cyanoethyl)-1,2,4-trioxolane (2b) as the first examples of their kind.Reduction with DMS yielded the expected fragments acetyl cyanide (4a) and β-cyanopropionyl cyanide (4b), along with formaldehyde.Reduction with triphenylphosphine, however, gave cyanomethyl acetate (6a) and cyanomethyl-β-cyanopropionate (6b), respectively.
