2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Base Information

Chemical Name:2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine
CAS No.:256219-18-8
Molecular Formula:C₂₅H₃₃F₂N₃O₅S
Molecular Weight:525.617
Hs Code.:

Synonyms:2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

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Chemical Property of 2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

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Technology Process of 2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

There total 5 articles about 2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3850-30-4
2,2-dimethyl-1-methylpropylamine

: 256219-15-5
2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

: 256219-18-8
2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Guidance literature:: In ethanol; at 20 ℃;
DOI:10.1021/jm990443h

Reference yield:

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 256219-18-8
2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / H₂SO₄; fumic nitric acid / 1 h / 20 °C

2: 69 percent / methanol / 8 h / Heating

3: 90 percent / Raney nickel; H₂ / methanol / 6 h / 50 - 55 °C

4: 65 percent / CH₂Cl₂ / 2 h / Heating

5: 97 percent / ethanol / 20 °C

With sulfuric acid; hydrogen; nitric acid; nickel; In methanol; ethanol; dichloromethane; 1: Nitration / 2: Cyclization / 3: Reduction / 4: thiophosgenation / 5: Addition;
DOI:10.1021/jm990443h

Reference yield:

: 145742-63-8
o-difluoromethoxy-5-nitrobenzaldehyde

: 256219-18-8
2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / methanol / 8 h / Heating

2: 90 percent / Raney nickel; H₂ / methanol / 6 h / 50 - 55 °C

3: 65 percent / CH₂Cl₂ / 2 h / Heating

4: 97 percent / ethanol / 20 °C

With hydrogen; nickel; In methanol; ethanol; dichloromethane; 1: Cyclization / 2: Reduction / 3: thiophosgenation / 4: Addition;
DOI:10.1021/jm990443h