(R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Base Information

Chemical Name:(R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
CAS No.:1430321-49-5
Molecular Formula:C₁₆H₂₃FN₂O₃Si
Molecular Weight:338.454
Hs Code.:

Synonyms:(R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Suppliers and Price of (R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

There total 9 articles about (R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1430321-43-9
benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate

: 60456-26-0
(R)-glycidyl butyrate

: 1430321-49-5
(R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Guidance literature:: benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

(R)-glycidyl butyrate; In tetrahydrofuran; at -78 - 25 ℃;

Reference yield: 58.0%

: 1430321-43-9
benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate

: 65031-96-1
(S)-glycidyl butyrate

: 1430321-49-5
(R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Guidance literature:: benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

(S)-glycidyl butyrate; In tetrahydrofuran; at -78 - 25 ℃;

Reference yield:

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

: 1430321-49-5
(R)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 8 h / 1810.07 Torr

2.1: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 - 25 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 25 °C

With n-butyllithium; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran;