1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

Base Information

Chemical Name:1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane
CAS No.:1430321-42-8
Molecular Formula:C₁₂H₁₇FN₂O₂Si
Molecular Weight:268.363
Hs Code.:

Synonyms:1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

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Chemical Property of 1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

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Technology Process of 1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

There total 4 articles about 1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 130596-62-2
4,4-dimethyl-4-silapiperidine hydrochloride

: 369-34-6
3,4-difluoronitrobenzene

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

Guidance literature:: 4,4-dimethyl-4-silapiperidine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

3,4-difluoronitrobenzene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1021/acs.jmedchem.0c00082

Reference yield:

: 10519-87-6
divinyldimethylsilane

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; dibenzoyl peroxide / n-heptane / 18.5 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / chloroform / 16 h / 60 °C / Inert atmosphere

3.1: hydrogenchloride / ethanol; water / Inert atmosphere

3.2: 20 h / 20 °C

4.1: triethylamine / ethyl acetate / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen bromide; triethylamine; dibenzoyl peroxide; In ethanol; n-heptane; chloroform; water; ethyl acetate;
DOI:10.1021/acsmedchemlett.5b00213

Reference yield:

: 51664-50-7
dimethylbis(2-bromoethyl)silane

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / chloroform / 16 h / 60 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol; water / Inert atmosphere

2.2: 20 h / 20 °C

3.1: triethylamine / ethyl acetate / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In ethanol; chloroform; water; ethyl acetate;
DOI:10.1021/acsmedchemlett.5b00213