Methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate

Base Information

Chemical Name:Methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate
CAS No.:33851-22-8
Molecular Formula:C₁₀H₇ClO₃S
Molecular Weight:242.683
Hs Code.:
DSSTox Substance ID:DTXSID00384034
Wikidata:Q82175923
Mol file:33851-22-8.mol

Synonyms:methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate;33851-22-8;METHYL 6-CHLORO-3-HYDROXY-1-BENZOTHIOPHENE-2-CARBOXYLATE;Methyl 6-chloro-3-hydroxybenzo(b)thiophene-2-carboxylate;Maybridge1_001092;SCHEMBL2578736;HMS544J14;DTXSID00384034;KCZUOINFDZHETR-UHFFFAOYSA-N;MFCD00052504;CCG-243999;FT-0765831;6-Chloro-3-hydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester;6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylic acid methyl ester

Suppliers and Price of Methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-6-CHLORO-3-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLATE 95.00%
5MG
$ 495.03

Advanced Chemicals Intermediatesced Chemicals Intermediates
6-Chloro-3-hydroxy-benzo[b]thiophene-2-carboxylicacidmethylester 95%+
250mg
$ 239.25

Acints
6-Chloro-3-hydroxy-benzo[b]thiophene-2-carboxylicacidmethylester 95%+
1g
$ 572.75

Total 2 raw suppliers

Chemical Property of Methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate

Chemical Property:

Melting Point:146-148°C
PSA：74.77000
LogP:3.04690
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:241.9804429
Heavy Atom Count:15
Complexity:261

Purity/Quality:

97% ^*data from raw suppliers

METHYL-6-CHLORO-3-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 20/21/22-36/37/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(C2=C(S1)C=C(C=C2)Cl)O

Technology Process of Methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate

There total 2 articles about Methyl 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42087-80-9
methyl 4-chloro-2-nitrobenzoate

: 2365-48-2
Methyl thioglycolate

: 33851-22-8
6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylic acid methyl ester

Guidance literature:: With lithium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2012.06.012

Reference yield:

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 33851-22-8
6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: lithium hydroxide / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; lithium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.06.012