1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

Base Information

Chemical Name:1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea
CAS No.:1448985-18-9
Molecular Formula:C₂₈H₃₂FN₇O₄
Molecular Weight:549.605
Hs Code.:

1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

Synonyms:1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

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Chemical Property of 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

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Technology Process of 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

There total 8 articles about 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 504-24-5
4-aminopyridine

: 75-44-5
phosgene

: 1448988-05-3
4-(4-amino-2-fluorophenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448985-18-9
1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

Guidance literature:: phosgene; 4-(4-amino-2-fluorophenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; toluene; at 50 ℃; for 0.5h; Inert atmosphere;

4-aminopyridine; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; for 3h;

Reference yield:

: 1448987-72-1
4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448985-18-9
1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 90 °C / Inert atmosphere

2.1: magnesium bis(monoperoxyphthalate)hexahydrate / acetonitrile; ethanol / 20 - 60 °C

3.1: 1,4-dioxane / 3 h / 95 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; toluene / 0.5 h / 50 °C / Inert atmosphere

5.2: 3 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; magnesium bis(monoperoxyphthalate)hexahydrate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1448988-03-1
[4-(6-ethyl-2-methanesulfonyl-8,8-dimethyl-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl)-3-fluorophenyl]carbamic acid tert-butyl ester

: 1448985-18-9
1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-pyridin-4-ylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 3 h / 95 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; toluene / 0.5 h / 50 °C / Inert atmosphere

3.2: 3 h

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; toluene;