2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid

Base Information

• Chemical Name: 2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid
• CAS No.: 854456-45-4
• Molecular Formula: C₃₇H₄₈FNO₈Si
• Molecular Weight: 681.874

Synonyms:2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid

Chemical Property of 2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid

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Technology Process of 2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid

There total 1 articles about 2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

tert-butyl (2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phenoxypropyl{[(2R)-6-hydroxy-3,4-dihydro-2H-chromen-2-yl]methyl}carbamate (854455-93-9) + 2-Bromo-5-fluorobenzoic acid (394-28-5) → 2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid (854456-45-4)

Guidance literature:

With dmap; copper; copper(II) oxide; In acetonitrile; at 20 ℃; Heating / reflux;

Reference yield: 82.0%

2-[((2R)-2-{[(tert-butoxycarbonyl)((2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phen-oxypropyl)amino]methyl}-3,4-dihydro-2H-chromen-6-yl)oxy]-5-fluorobenzoic acid (854456-45-4) → 5-fluoro-2-{[(2R)-2-({[(2S)-2-hydroxy-3-phenoxypropyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]oxy}benzoic acid hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

upstream raw materials:

tert-butyl (2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3-phenoxypropyl{[(2R)-6-hydroxy-3,4-dihydro-2H-chromen-2-yl]methyl}carbamate

2-Bromo-5-fluorobenzoic acid

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