2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

Base Information

Chemical Name:2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester
CAS No.:1621363-36-7
Molecular Formula:C₁₉H₁₇N₃O₃S
Molecular Weight:367.428
Hs Code.:

Synonyms:2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

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Chemical Property of 2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

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Technology Process of 2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

There total 4 articles about 2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1621363-01-6
2-(4-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methyl ester

: 157025-33-7
5-(tributylstannanyl)-1,3-thiazole

: 1621363-36-7
2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 130 ℃; for 2h;

Reference yield:

: 5466-43-3
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine

: 1621363-36-7
2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 2 h / Reflux

2: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 130 °C

With bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 10472-24-9,265317-94-0
methyl 2-oxocyclopentane-1-carboxylate

: 1621363-36-7
2-(4-(2-(thiazol-5-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methylester

Guidance literature:: Multi-step reaction with 4 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 0 - 20 °C

2: trichlorophosphate; sodium hydrogencarbonate / 24 h / 85 - 100 °C / Cooling with ice

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 2 h / Reflux

4: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 130 °C

With bis-triphenylphosphine-palladium(II) chloride; chloro-trimethyl-silane; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;