5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole
CAS No.:1136832-67-1
Molecular Formula:C₂₁H₁₂F₄N₂O₂
Molecular Weight:400.332
Hs Code.:

Synonyms:5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

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Technology Process of 5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

There total 6 articles about 5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1138697-97-8
(Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime)

: 1136832-67-1
5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield: 54.0%

: 860004-31-5
4-(4-(trifluoromethyl)phenoxy)benzonitrile

: 824-75-9
p-fluorobenzamide

: 1136832-67-1
5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Guidance literature:: With copper(l) iodide; 2,9-diphenyl-1,10-phenanthroline; oxygen; potassium carbonate; zinc(II) iodide; In 1,2-dichloro-benzene; at 130 ℃; for 24h; under 760.051 Torr; Schlenk technique; Molecular sieve;
DOI:10.1002/ejoc.201501502

Reference yield:

: 3058-39-7
4-iodobenzonitrile

: 1136832-67-1
5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) iodide / 1,4-dioxane / 140 h / 90 °C / Inert atmosphere

2: hydroxylamine / ethanol / 1 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 h / 0 - 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrabutyl ammonium fluoride; hydroxylamine; N,N-dimethylglycine hydrochoride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/ja500053x