(Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime)

Base Information

• Chemical Name: (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime)
• CAS No.: 1138697-97-8
• Molecular Formula: C₂₁H₁₄F₄N₂O₃
• Molecular Weight: 418.347
• Mol file: 1138697-97-8.mol

Synonyms:(Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime)

Chemical Property of (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime)

There total 4 articles about (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(Z)-N′-hydroxy-4-(4-(trifluoromethyl)phenoxy)benzimidamide (1087782-00-0,1136832-69-3) + 4-fluorobenzoyl chloride (403-43-0) → (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime) (1138697-97-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 25h;

Reference yield:

4-iodobenzonitrile (3058-39-7) → (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime) (1138697-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) iodide / 1,4-dioxane / 140 h / 90 °C / Inert atmosphere

2: hydroxylamine / ethanol / 1 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; hydroxylamine; N,N-dimethylglycine hydrochoride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1021/ja500053x

Reference yield:

4-(4-(trifluoromethyl)phenoxy)benzonitrile (860004-31-5) → (Z)-4-(4-(trifluoromethyl)phenoxy)-O-(4-(4-fluorobenzoyl)benzamidoxime) (1138697-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine / ethanol / 1 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 h / 0 - 20 °C / Inert atmosphere

With hydroxylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1021/ja500053x

upstream raw materials:

(Z)-N′-hydroxy-4-(4-(trifluoromethyl)phenoxy)benzimidamide

4-fluorobenzoyl chloride

4-hydroxybenzotrifluoride

4-iodobenzonitrile

Downstream raw materials:

5-(4-fluorophenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole