(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

Base Information

Chemical Name:(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt
CAS No.:1620056-61-2
Molecular Formula:C₂HF₃O₂*C₂₂H₂₁ClF₂N₆O₂S
Molecular Weight:620.987
Hs Code.:

Synonyms:(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

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Chemical Property of (S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

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Technology Process of (S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

There total 10 articles about (S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620056-59-8
(S)-tert-butyl (1-(5-amino-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

: 76-05-1
trifluoroacetic acid

: 1620056-61-2
(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 186593-43-1
5-amino-3-bromo-2-methylpyridine

: 1620056-61-2
(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

Guidance literature:: Multi-step reaction with 9 steps

1: sodium acetate; acetic acid / Reflux

2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

3: copper(II) sulfate / dichloromethane / 2 h / 20 °C

4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 °C

7: hydrazine hydrate / ethanol / 2 h / 20 °C

8: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 150 °C / Sealed tube; Inert atmosphere

9: dichloromethane / 1 h / 20 °C

With hydrogenchloride; selenium(IV) oxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium acetate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; hydrazine hydrate; copper(II) sulfate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 1620056-30-5
2-(5-bromo-6-methylpyridin-3-yl)isoindoline-1,3-dione

: 1620056-61-2
(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

Guidance literature:: Multi-step reaction with 8 steps

1: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

2: copper(II) sulfate / dichloromethane / 2 h / 20 °C

3: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

4: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 °C

6: hydrazine hydrate / ethanol / 2 h / 20 °C

7: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 150 °C / Sealed tube; Inert atmosphere

8: dichloromethane / 1 h / 20 °C

With hydrogenchloride; selenium(IV) oxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; hydrazine hydrate; copper(II) sulfate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;