2-CHLORO-N'-(DIPHENYLMETHYLENE)PROPANOHYDRAZIDE

Base Information

• Chemical Name: 2-CHLORO-N'-(DIPHENYLMETHYLENE)PROPANOHYDRAZIDE
• CAS No.: 79289-07-9
• Molecular Formula: C16H15ClN2O
• Molecular Weight: 286.761
• Mol file: 79289-07-9.mol

Synonyms:HMS2698E05;9N-360S;

Chemical Property of 2-CHLORO-N'-(DIPHENYLMETHYLENE)PROPANOHYDRAZIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 41.46000
• Density: 1.15g/cm³
• LogP: 3.57340

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-N'-(DIPHENYLMETHYLENE)PROPANOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N'-(DIPHENYLMETHYLENE)PROPANOHYDRAZIDE

There total 1 articles about 2-CHLORO-N'-(DIPHENYLMETHYLENE)PROPANOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloropropionyl chloride (7623-09-8) + benzophenone hydrazone (5350-57-2) → benzophenone α-chloropropionylhydrazone (79289-07-9)

Guidance literature:

With pyridine; In dichloromethane; for 0.25h; Heating;

DOI:10.1021/ja00416a009

Reference yield: 63.0%

benzophenone α-chloropropionylhydrazone (79289-07-9) → 1-(diphenylmethylene)-4-methyl-3-oxo-1,2-diazetidinium hydroxide, inner salt (79289-32-0) + Acrylic acid benzhydrylidene-hydrazide (79289-70-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 80 ℃; for 4h; Heating;

DOI:10.1021/ja00416a009

Reference yield:

benzophenone α-chloropropionylhydrazone (79289-07-9) → 1-benzhydryl-4-methyldiazetidin-3-one (21083-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / 53percent sodium hydride / tetrahydrofuran / 4 h / 80 °C / Heating

2: 55 percent / sodium borohydride / methanol / 1 h / 0 °C

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1021/ja00416a009

upstream raw materials:

2-chloropropionyl chloride

benzophenone hydrazone

Downstream raw materials:

1-(diphenylmethylene)-4-methyl-3-oxo-1,2-diazetidinium hydroxide, inner salt

Acrylic acid benzhydrylidene-hydrazide

1-benzhydryl-4-methyldiazetidin-3-one

5,5-diphenyl-3,4-bis(carbomethoxy)-Δ²-pyrazolidine

Refernces