1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

Base Information

Chemical Name:1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride
CAS No.:1338349-06-6
Molecular Formula:C₂₆H₃₃FN₂O*ClH
Molecular Weight:445.02
Hs Code.:

Synonyms:1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

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Chemical Property of 1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

Chemical Property:

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Technology Process of 1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

There total 6 articles about 1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₇FN₂O*ClH

: 100-52-7
benzaldehyde

: 1338349-06-6
1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

Guidance literature:: C₁₉H₂₇FN₂O*ClH; benzaldehyde; With sodium acetate; sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 15h;

With hydrogenchloride; In ethyl acetate;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 111-24-0
1,5-dibromo-pentane

: 1338349-06-6
1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Cooling with ice

2: ammonium hydroxide; hydrogen / ethanol / 23 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 26 h / 20 °C

4: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

5: sodium acetate; sodium tris(acetoxy)borohydride / dichloromethane / 15 h / 20 °C

With hydrogenchloride; ammonium hydroxide; hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 71486-43-6
1-(4-fluorophenyl)cyclohexanecarbonitrile

: 1338349-06-6
1-benzyl-N-{[1-(4-fluorophenyl)cyclohexyl]methyl}piperidine-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide; hydrogen / ethanol / 23 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 26 h / 20 °C

3: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

4: sodium acetate; sodium tris(acetoxy)borohydride / dichloromethane / 15 h / 20 °C

With hydrogenchloride; ammonium hydroxide; hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.030