3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

Base Information

Chemical Name:3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile
CAS No.:1103506-79-1
Molecular Formula:C₂₂H₁₅N₅O₂
Molecular Weight:381.393
Hs Code.:

Synonyms:3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

There total 8 articles about 3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1103508-21-9
3-(6-oxo-1-{3-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-benzyl}-1,6-dihydropyridazin-3-yl)-benzonitrile

: 1103506-79-1
3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

Guidance literature:: With sodium perborate; In tetrahydrofuran; dichloromethane; water; at 20 ℃; Cooling with ice;

Reference yield:

: 1092568-90-5
(3-(5-bromopyrimidin-2-yl)phenyl)methanol

: 1103506-79-1
3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 3 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 72 h / 40 °C / Inert atmosphere

3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere

4: water / tetrahydrofuran / 2 h / 20 °C

With thionyl chloride; water; potassium acetate; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1103506-79-1
3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate tribasic trihydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 3 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 72 h / 40 °C / Inert atmosphere

4: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere

5: water / tetrahydrofuran / 2 h / 20 °C

With thionyl chloride; potassium phosphate tribasic trihydrate; water; potassium acetate; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;