(2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide

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Chemical Name:(2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide
CAS No.:745051-60-9
Molecular Formula:C₁₈H₂₂N₂O₄S₂
Molecular Weight:394.516
Hs Code.:
Mol file:745051-60-9.mol

Synonyms:(2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide Edit

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Technology Process of (2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide

There total 3 articles about (2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 745053-46-7
(R)-2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid

: 6142-05-8
aminothiazole hydrochloric acid

: 745051-60-9
(2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide

Guidance literature:: (R)-2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at -20 ℃; for 1h;

With 2,3,5-trimethyl-pyridine; In dichloromethane; for 0.25h;

aminothiazole hydrochloric acid; In dichloromethane; at -15 - 20 ℃; for 4h;
DOI:10.1021/jm8003202

Reference yield:

: 96-50-4
2-thiazolylamine

: 745051-60-9
(2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide

Guidance literature:: (R)-2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid; With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1h;

2-thiazolylamine; With pyridine; In dichloromethane; at 0 - 20 ℃; for 20h;