tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

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Chemical Name:tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate
CAS No.:935289-88-6
Molecular Formula:C₂₆H₂₆ClN₃O₃
Molecular Weight:463.964
Hs Code.:

Synonyms:tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

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Chemical Property of tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

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Technology Process of tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

There total 3 articles about tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935289-83-1
3,5-dichloro-1-[(1R)-1-phenylethyl]-2(1H)-pyrazinone

: 96551-21-2
1-(t-butyloxycarbonyl)-3-(bromomethyl)indole

: 935289-88-6
tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

Guidance literature:: 3,5-dichloro-1-[(1R)-1-phenylethyl]-2(1H)-pyrazinone; With bis(tri-n-butyltin); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 24h;

1-(t-butyloxycarbonyl)-3-(bromomethyl)indole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 48h; Further stages.;
DOI:10.1002/ejoc.200600805

Reference yield:

: 35341-74-3
(R)-2-((1-phenylethyl)amino)acetonitrile

: 935289-88-6
tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / chlorobenzene; diethyl ether / 0.58 h / 0 - 20 °C

1.2: 23.0 g / Et₃N*HCl / chlorobenzene / 48 h / 20 °C

2.1: (Bu₃Sn)2 / Pd(PPh₃)4 / toluene / 24 h / 110 °C

2.2: 0.264 g / Pd(PPh₃)4 / toluene / 48 h / 110 °C

With hydrogenchloride; bis(tri-n-butyltin); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; chlorobenzene; toluene; 2.2: Stille coupling;
DOI:10.1002/ejoc.200600805

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 935289-88-6
tert-butyl 3-({ 6-chloro-3-oxo-4-[(1R)-1-phenylethyl]-3,4-dihydro-2-pyrazinyl}methyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Na₂S₂O₅ / H₂O / 4 h / 60 °C

1.2: H₂O / 15 h / 60 °C

2.1: HCl / chlorobenzene; diethyl ether / 0.58 h / 0 - 20 °C

2.2: 23.0 g / Et₃N*HCl / chlorobenzene / 48 h / 20 °C

3.1: (Bu₃Sn)2 / Pd(PPh₃)4 / toluene / 24 h / 110 °C

3.2: 0.264 g / Pd(PPh₃)4 / toluene / 48 h / 110 °C

With hydrogenchloride; sodium metabisulfite; bis(tri-n-butyltin); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; water; chlorobenzene; toluene; 3.2: Stille coupling;
DOI:10.1002/ejoc.200600805