2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

Base Information

Chemical Name:2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid
CAS No.:1301167-88-3
Molecular Formula:C₄H₆O₄*C₂₄H₂₃FN₄O
Molecular Weight:520.56
Hs Code.:

Synonyms:2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

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Chemical Property of 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

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Technology Process of 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

There total 5 articles about 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202932-05-6
2-hydroxymethyl-3,5-dimethylpyridine

: 1301167-88-3
2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

Guidance literature:: With sodium carbonate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 1301167-63-4
4-(3-(4-(benzyloxy)phenyl)-1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyridine

: 1301167-88-3
2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 80 °C / 760.05 Torr

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation

3: methanol

With di-tert-butyl-diazodicarboxylate; 5%-palladium/activated carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm200536d

Reference yield:

: 898563-86-5
4-[3-(4-benzyloxyphenyl)-1H-pyrazol-4-yl]pyridine

: 1301167-88-3
2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.08 h / 150 °C / Microwave irradiation

2: 5%-palladium/activated carbon; hydrogen / ethanol / 80 °C / 760.05 Torr

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation

4: methanol

With di-tert-butyl-diazodicarboxylate; 5%-palladium/activated carbon; hydrogen; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200536d