<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

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Chemical Name:<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile
CAS No.:134734-09-1
Molecular Formula:C₂₃H₂₆N₂O₅
Molecular Weight:410.47
Hs Code.:

Synonyms:<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

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Chemical Property of <6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

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Technology Process of <6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

There total 5 articles about <6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 151-50-8
potassium cyanide

: 134734-01-3
6-acetoxy-2-(3,4-dimethoxyphenyl)-tetrahydro-2H-pyran-3-one

: 100-46-9
benzylamine

: 134734-09-1
<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

Guidance literature:: With acetic acid; In methanol;
DOI:10.1002/jhet.5570280325

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 134734-09-1
<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / n-BuLi / hexane; diethyl ether; tetrahydrofuran / 3 h / Ambient temperature

2: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 7 - 15 °C

3: 93 percent / DMAP, DCC / CH₂Cl₂ / Ambient temperature

4: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

5: 89 percent / gl. acetic acid / methanol

With dmap; n-butyllithium; hydrogen; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate;
DOI:10.1002/jhet.5570280325

Reference yield:

: 134733-96-3
α-(3,4-dimethoxyphenyl)furfuryl alcohol

: 134734-09-1
<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 7 - 15 °C

2: 93 percent / DMAP, DCC / CH₂Cl₂ / Ambient temperature

3: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

4: 89 percent / gl. acetic acid / methanol

With dmap; hydrogen; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1002/jhet.5570280325