prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

Base Information

Chemical Name:prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate
CAS No.:1439879-02-3
Molecular Formula:C₂₉H₂₃F₃N₄O₆
Molecular Weight:580.52
Hs Code.:

Synonyms:prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

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Chemical Property of prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

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Technology Process of prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

There total 14 articles about prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57933-83-2
Isopropenyl chloroformate

: 1322759-09-0
N-(4-((2-aminopyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 1439879-02-3
prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

Guidance literature:: With pyridine; at 15 - 25 ℃;

Reference yield:

: 35260-93-6,932750-29-3
ethyl 2-cyano-3-ethoxybut-2-enoate

: 1439879-02-3
prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: 2 h / 70 °C

2: acetic acid / Reflux

3: copper diacetate; pyridine / dichloromethane / 4 h / 15 - 25 °C

4: lithium hydroxide; water / ethanol / 16 h / 15 - 25 °C

5: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

6: triethylamine / tetrahydrofuran / 15 - 25 °C

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

8: potassium carbonate; ethanol / 1 h / 120 °C / Microwave irradiation

9: pyridine / 15 - 25 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; ethanol; water; copper diacetate; potassium carbonate; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1439879-02-3
prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 15 - 25 °C

1.2: 1.17 h

2.1: hydrogen / methanol / 4 h / 517.16 - 1034.32 Torr

3.1: triethylamine / tetrahydrofuran / 15 - 25 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

5.1: potassium carbonate; ethanol / 1 h / 120 °C / Microwave irradiation

6.1: pyridine / 15 - 25 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; hydrogen; potassium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;