1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

Base Information

Chemical Name:1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea
CAS No.:1439877-33-4
Molecular Formula:C₂₆H₂₁F₃N₆O₄
Molecular Weight:538.486
Hs Code.:

Synonyms:1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

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Chemical Property of 1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

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Technology Process of 1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

There total 14 articles about 1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439879-02-3
prop-1-en-2-yl (4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2,5-difluorophenoxy)pyridin-2-yl)carbamate

: 74-89-5
methylamine

: 1439877-33-4
1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

Guidance literature:: With 1-Methylpyrrolidine; In tetrahydrofuran; at 15 - 25 ℃; for 3h;

Reference yield:

: 35260-93-6,932750-29-3
ethyl 2-cyano-3-ethoxybut-2-enoate

: 1439877-33-4
1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

Guidance literature:: Multi-step reaction with 10 steps

1: 2 h / 70 °C

2: acetic acid / Reflux

3: copper diacetate; pyridine / dichloromethane / 4 h / 15 - 25 °C

4: lithium hydroxide; water / ethanol / 16 h / 15 - 25 °C

5: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

6: triethylamine / tetrahydrofuran / 15 - 25 °C

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

8: potassium carbonate; ethanol / 1 h / 120 °C / Microwave irradiation

9: pyridine / 15 - 25 °C

10: 1-Methylpyrrolidine / tetrahydrofuran / 3 h / 15 - 25 °C

With 1-Methylpyrrolidine; pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; ethanol; water; copper diacetate; potassium carbonate; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1439877-33-4
1-(4-(2,5-difluoro-4-(1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)pyridin-2-yl)-3-methylurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 15 - 25 °C

1.2: 1.17 h

2.1: hydrogen / methanol / 4 h / 517.16 - 1034.32 Torr

3.1: triethylamine / tetrahydrofuran / 15 - 25 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

5.1: potassium carbonate; ethanol / 1 h / 120 °C / Microwave irradiation

6.1: pyridine / 15 - 25 °C

7.1: 1-Methylpyrrolidine / tetrahydrofuran / 3 h / 15 - 25 °C

With 1-Methylpyrrolidine; pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; hydrogen; potassium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;