(S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester
CAS No.:120686-39-7
Molecular Formula:C₃₂H₃₆N₂O₅
Molecular Weight:528.648
Hs Code.:

Synonyms:(S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Suppliers and Price of (S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

There total 6 articles about (S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 120686-30-8
(E)-3-((S)-1-tert-Butoxycarbonylmethyl-2-phenyl-ethylcarbamoyl)-4-phenyl-but-3-enoic acid

: 120686-39-7
(S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; 1.) 0 deg C, 1 h, 2.) r.t., overnight;
DOI:10.1021/jm00127a017

Reference yield:

: 26250-86-2
(S)-3-benzyloxycarbonylamino-4-phenylbutyric acid

: 120686-39-7
(S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 0.5 h / Heating

2: hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature

3: 87.8 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

4: 51.5 percent / 1 M NaOH / ethanol; H₂O / 1.) 0 deg C, 1 h, 2.) r.t., 5 h

5: 61.4 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water; benzene;
DOI:10.1021/jm00127a017

Reference yield:

: 200267-79-4
(S)-3-Benzyloxycarbonylamino-4-phenyl-butyric acid tert-butyl ester

: 120686-39-7
(S)-3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-4-phenyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature

2: 87.8 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

3: 51.5 percent / 1 M NaOH / ethanol; H₂O / 1.) 0 deg C, 1 h, 2.) r.t., 5 h

4: 61.4 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water;
DOI:10.1021/jm00127a017