(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

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Chemical Name:(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate
CAS No.:1615696-52-0
Molecular Formula:C₂₅H₃₃ClFN₆O₈P
Molecular Weight:630.998
Hs Code.:

(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Synonyms:(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

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Chemical Property of (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

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Technology Process of (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

There total 11 articles about (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1615696-51-9
C₄₅H₄₉ClFN₆O₉P

: 1615696-52-0
(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Guidance literature:: With acetic acid; In water; at 20 ℃; for 12h;

Reference yield:

: 1615696-39-3
C₂₁H₂₃FO₅

: 1615696-52-0
(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / acetic acid / 12 h / 0 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 - 60 °C

3.1: silver nitrate; 2,3,5-trimethyl-pyridine / dichloromethane / 12 h / 20 °C

4.1: 3-hydroxylacrylic nitrile; sodium hydride / tetrahydrofuran / 12.5 h / 0 - 20 °C

5.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

5.2: 2 h / 0 - 20 °C

6.1: acetic acid / water / 12 h / 20 °C

With 2,3,5-trimethyl-pyridine; sulfuric acid; tert-butylmagnesium chloride; sodium hydride; 3-hydroxylacrylic nitrile; silver nitrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; acetic acid; acetonitrile;

Reference yield:

: 946511-98-4
(S)-1-(neopentyloxy)-1-oxopropan-2-aminium chloride

: 1615696-52-0
(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate; triethylamine / dichloromethane / 2 h / -78 - 20 °C

1.2: 2 h / -78 - 20 °C

2.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

3.1: acetic acid / water / 12 h / 20 °C

With tert-butylmagnesium chloride; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; water;