1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 938062-95-4
• Molecular Formula: C₃₂H₂₉BrN₄O₅S₂
• Molecular Weight: 693.642
• Mol file: 938062-95-4.mol

Synonyms:1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine

There total 4 articles about 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4,6-dibenzylthio-3-bromo-1H-pyrazolo[3,4-d]pyrimidine (938062-83-0) + (3-acetoxy-2-O-benzoyl-1-propoxy)methyl bromide (380897-71-2) → 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine (938062-95-4)

Guidance literature:

With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; at 40 ℃; for 1h;

DOI:10.1080/15257770600793802

Reference yield:

4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine (938062-78-3) → 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine (938062-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / N-bromosuccinimide / 1,2-dichloro-ethane / 0.5 h / Heating

2: 76 percent / 18-crown-6; potassium tert-butoxide / tetrahydrofuran / 1 h / 40 °C

With N-Bromosuccinimide; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1080/15257770600793802

Reference yield:

benzyl bromide (100-39-0) → 1-(3-acetoxy-2-benzoyloxy-1-propoxy)methyl-3-bromo-4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine (938062-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / NaOH / 3 h / 20 °C

2: 83 percent / N-bromosuccinimide / 1,2-dichloro-ethane / 0.5 h / Heating

3: 76 percent / 18-crown-6; potassium tert-butoxide / tetrahydrofuran / 1 h / 40 °C

With sodium hydroxide; N-Bromosuccinimide; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1080/15257770600793802

upstream raw materials:

4,6-dibenzylthio-3-bromo-1H-pyrazolo[3,4-d]pyrimidine

(3-acetoxy-2-O-benzoyl-1-propoxy)methyl bromide

4,6-dibenzylthio-1H-pyrazolo[3,4-d]pyrimidine

benzyl bromide