(Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

Base Information

Chemical Name:(Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one
CAS No.:1571062-00-4
Molecular Formula:C₁₇H₁₈ClNO₅
Molecular Weight:351.787
Hs Code.:

Synonyms:(Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

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Chemical Property of (Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

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Technology Process of (Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

There total 7 articles about (Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 90-50-6
3,4,5-trimethoxycinnamic acid

: 207976-92-9
3-chloro-5,6-dihydro-1H-pyridin-2-one

: 1571062-00-4
(Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

Guidance literature:: 3,4,5-trimethoxycinnamic acid; With oxalyl dichloride; In tetrahydrofuran; for 4h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h;

3-chloro-5,6-dihydro-1H-pyridin-2-one; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield: 45.0%

: 10263-19-1,89652-61-9
(E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride

: 207976-92-9
3-chloro-5,6-dihydro-1H-pyridin-2-one

: 1571062-00-4
(Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

Guidance literature:: 3-chloro-5,6-dihydro-1H-pyridin-2-one; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

(E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride; In tetrahydrofuran; at -78 - 23 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.cclet.2020.08.049

Reference yield:

: 675-20-7
piperidin-2-one

: 1571062-00-4
(Ε)-3-chloro-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1Η)-one

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus pentachloride / chloroform / 3.25 h / 0 °C / Reflux

2: lithium carbonate / N,N-dimethyl-formamide / 7 h / 120 °C

3: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With phosphorus pentachloride; lithium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.05.070