dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

Base Information

Chemical Name:dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate
CAS No.:1380347-20-5
Molecular Formula:C₁₈H₁₇ClNO₅P
Molecular Weight:393.763
Hs Code.:

Synonyms:dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

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Chemical Property of dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

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Technology Process of dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

There total 6 articles about dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1380347-36-3
N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

: 756-79-6
dimethyl methane phosphonate

: 1380347-20-5
dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In hexane; toluene; at -78 ℃; for 1h; Inert atmosphere;

N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide; In hexane; toluene; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: C₂₀H₁₈ClNO₅

: 1380347-20-5
dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 1,2-dimethoxyethane; water / 2 h / 60 °C

1.2: 2 h / 60 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 6 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / hexane; toluene / 1 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; hexane; water; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 1380347-35-2
2-(3-iodophenyl)-5-chloro-1,3-benzoxazole

: 1380347-20-5
dimethyl (3-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-oxopropyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,3-dimethyl-2-imidazolidinone; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 120 °C / Inert atmosphere

2.1: sodium hydroxide / 1,2-dimethoxyethane; water / 2 h / 60 °C

2.2: 2 h / 60 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 6 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / hexane; toluene / 1 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,3-dimethyl-2-imidazolidinone; 1,2-dimethoxyethane; hexane; water; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.008