N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

Base Information

Chemical Name:N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide
CAS No.:1380347-36-3
Molecular Formula:C₁₇H₁₅ClN₂O₃
Molecular Weight:330.771
Hs Code.:

Synonyms:N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

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Chemical Property of N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

Chemical Property:

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Technology Process of N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

There total 4 articles about N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225168-81-9
C₁₅H₁₀ClNO₃

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1380347-36-3
N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 1380347-35-2
2-(3-iodophenyl)-5-chloro-1,3-benzoxazole

: 1380347-36-3
N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,3-dimethyl-2-imidazolidinone; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 120 °C / Inert atmosphere

2.1: sodium hydroxide / 1,2-dimethoxyethane; water / 2 h / 60 °C

2.2: 2 h / 60 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 6 h / 20 °C / Inert atmosphere

With sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,3-dimethyl-2-imidazolidinone; 1,2-dimethoxyethane; water; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: C₂₀H₁₈ClNO₅

: 1380347-36-3
N-methoxy-N-methyl-2-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 1,2-dimethoxyethane; water / 2 h / 60 °C

1.2: 2 h / 60 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 6 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; water; acetonitrile;
DOI:10.1016/j.bmc.2012.04.008