diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Base Information

Chemical Name:diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate
CAS No.:454472-39-0
Molecular Formula:C₄₉H₄₀ClN₇O₅S₃
Molecular Weight:938.551
Hs Code.:

Synonyms:diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Suppliers and Price of diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

There total 3 articles about diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 71445-30-2
α-syn-methoxyimino-α-(2-amino-5-chlorothiazol-4-yl)-acetic acid

: 189099-17-0
diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

: 454472-39-0
diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: α-syn-methoxyimino-α-(2-amino-5-chlorothiazol-4-yl)-acetic acid; With potassium carbonate; methanesulfonyl chloride; In N,N-dimethyl acetamide; at 5 ℃; for 0.5h;

diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate; With benzenesulfonamide; In N,N-dimethyl acetamide; at 5 ℃; for 1h;
DOI:10.1016/S0968-0896(01)00416-3

Reference yield:

: 74704-03-3
diphenylmethyl 7β-amino-3-methanesulfonyloxy-3-cephem-4-carboxylate

: 454472-39-0
diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaSH; i-Pr₂NEt / dimethylformamide / 1 h / -20 °C

1.2: 56 percent / dimethylformamide / 1 h / -5 °C

2.1: K₂CO₃; MeSO₂Cl / N,N-dimethyl-acetamide / 0.5 h / 5 °C

2.2: 64 percent / BSA / N,N-dimethyl-acetamide / 1 h / 5 °C

With sodium hydrogensulfide; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00416-3

Reference yield:

: 4-chloromethyl-1-tritylpyrazole

: 454472-39-0
diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaSH; i-Pr₂NEt / dimethylformamide / 1 h / -20 °C

1.2: 56 percent / dimethylformamide / 1 h / -5 °C

2.1: K₂CO₃; MeSO₂Cl / N,N-dimethyl-acetamide / 0.5 h / 5 °C

2.2: 64 percent / BSA / N,N-dimethyl-acetamide / 1 h / 5 °C

With sodium hydrogensulfide; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00416-3