1-Phenyl-1-phenylsulfanylpropan-2-one

Base Information

• Chemical Name: 1-Phenyl-1-phenylsulfanylpropan-2-one
• CAS No.: 10371-49-0
• Molecular Formula: C₁₅H₁₄OS
• Molecular Weight: 242.342
• DSSTox Substance ID: DTXSID201293228
• Nikkaji Number: J718.650I
• Mol file: 10371-49-0.mol

Synonyms:1-Phenyl-1-(phenylthio)-2-propanone;1-phenyl-1-phenylsulfanylpropan-2-one;1-phenyl-1-phenylsulfanyl-propan-2-one;SCHEMBL4262200;CKZNBARGNLSAQG-UHFFFAOYSA-N;DTXSID201293228;1-phenyl-1-(phenylsulfanyl)acetone;10371-49-0

Chemical Property of 1-Phenyl-1-phenylsulfanylpropan-2-one

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 242.07653624
• Heavy Atom Count: 17
• Complexity: 239

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C(C1=CC=CC=C1)SC2=CC=CC=C2

Technology Process of 1-Phenyl-1-phenylsulfanylpropan-2-one

There total 8 articles about 1-Phenyl-1-phenylsulfanylpropan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diphenyldisulfane (882-33-7) + 1-phenyl-acetone (103-79-7,136675-26-8) → 1-phenyl-1-(phenylthio)-2-propenone (10371-49-0)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1055/s-1980-29271

Reference yield: 85.0%

1-chloro-1-phenylthio-2-propanone (69753-43-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-phenyl-1-(phenylthio)-2-propenone (10371-49-0)

Guidance literature:

With tin(IV) chloride; Ambient temperature;

DOI:10.1016/S0040-4039(00)81343-X

Reference yield: 64.0%

1-Phenyl-1-phenylsulfanyl-propan-2-ol (115205-58-8) → 1-phenyl-1-(phenylthio)-2-propenone (10371-49-0)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -50 - -20 ℃; for 1h;

DOI:10.1021/ja00223a060

upstream raw materials:

sodium thiophenolate

2-methyl-2-nitro-3-phenyloxirane

1-Phenyl-1-phenylsulfanyl-propan-2-ol

diphenyldisulfane

Downstream raw materials:

1-chloro-1-phenyl-1-phenylthio-2-propanone

(E)-3-Methyl-4-phenyl-4-phenylsulfanyl-but-3-enoic acid ethyl ester

1-phenyl-acetone

3-Methyl-4-oxo-4-phenyl-butansaeure-ethylester