(R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

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Chemical Name:(R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide
CAS No.:1194096-49-5
Molecular Formula:C₂₁H₂₅F₂N₅O₂
Molecular Weight:417.459
Hs Code.:

Synonyms:(R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

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Chemical Property of (R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

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Technology Process of (R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

There total 5 articles about (R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-difluoro-phenyl)-propionamide dihydrochloride

: 475-11-6,58123-62-9,68078-09-1
N-methyl-D-proline

: 1194096-49-5
(R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

Guidance literature:: (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-difluoro-phenyl)-propionamide dihydrochloride; N-methyl-D-proline; With benzotriazol-1-ol; N,N-dimethyl-formamide; In dichloromethane; water; at 0 ℃; for 0.25h; water soluble carbodiimide;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; water; at 0 - 20 ℃; for 5h;

Reference yield:

: 4214-73-7
6-aminonicotinonitrile

: 1194096-49-5
(R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / palladium on activated charcoal / water / 18 h / 517.16 Torr

2.1: benzotriazol-1-ol; N,N-dimethyl-formamide / dichloromethane; water / 0.25 h / 0 °C / water soluble carbodiimide

2.2: 5 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane

4.1: benzotriazol-1-ol; N,N-dimethyl-formamide / dichloromethane; water / 0.25 h / 0 °C / water soluble carbodiimide

4.2: 5 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; N,N-dimethyl-formamide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 198474-90-7,1214041-87-8,205445-51-8
(S)-2-((tert-butoxycarbonyl)amino)-3-(3,4-difluorophenyl)propanoic acid

: 1194096-49-5
(R)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; N,N-dimethyl-formamide / dichloromethane; water / 0.25 h / 0 °C / water soluble carbodiimide

1.2: 5 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane

3.1: benzotriazol-1-ol; N,N-dimethyl-formamide / dichloromethane; water / 0.25 h / 0 °C / water soluble carbodiimide

3.2: 5 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;