p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

Base Information

Chemical Name:p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate
CAS No.:1026059-78-8
Molecular Formula:C₃₀H₃₃N₅O₆S
Molecular Weight:591.688
Hs Code.:

Synonyms:p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

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Chemical Property of p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

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Technology Process of p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

There total 7 articles about p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 342811-99-8
3-(imidazo[1,2-b]pyridazine-6-yl)propanal

: p-methoxybenzyl 7β-t-butoxycarbonylamino-3-(triphenylphosphonium)methyl-3-cephem-4-carboxylate iodide

: 1026059-78-8
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

Guidance literature:: p-methoxybenzyl 7β-t-butoxycarbonylamino-3-(triphenylphosphonium)methyl-3-cephem-4-carboxylate iodide; With sodium hydroxide; sodium chloride; In chloroform; water; at 20 ℃; for 1h;

3-(imidazo[1,2-b]pyridazine-6-yl)propanal; In chloroform; at 20 ℃; for 24h;

With iodine; In toluene; at 100 ℃; for 40h;
DOI:10.7164/antibiotics.54.257

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1026059-78-8
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5.1 mg / N-trimethylsilylacetamide / CH₂Cl₂ / 15 h / 20 °C

2.1: NaI / butan-2-one / 1 h / 20 °C

3.1: 6.08 g / toluene / 1 h / 20 °C

4.1: NaOH; NaCl / H₂O; CHCl₃ / 1 h / 20 °C

4.2: CHCl₃ / 24 h / 20 °C

4.3: 32 percent / iodine / toluene / 40 h / 100 °C

With sodium hydroxide; N-Trimethylsilylacetamide; sodium iodide; sodium chloride; In dichloromethane; chloroform; water; toluene; butanone; 4.2: Wittig reaction;
DOI:10.7164/antibiotics.54.257

Reference yield:

: 106773-36-8
4-methoxybenzyl-7-amino-3-chloromethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

: 1026059-78-8
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5.1 mg / N-trimethylsilylacetamide / CH₂Cl₂ / 15 h / 20 °C

2.1: NaI / butan-2-one / 1 h / 20 °C

3.1: 6.08 g / toluene / 1 h / 20 °C

4.1: NaOH; NaCl / H₂O; CHCl₃ / 1 h / 20 °C

4.2: CHCl₃ / 24 h / 20 °C

4.3: 32 percent / iodine / toluene / 40 h / 100 °C

With sodium hydroxide; N-Trimethylsilylacetamide; sodium iodide; sodium chloride; In dichloromethane; chloroform; water; toluene; butanone; 4.2: Wittig reaction;
DOI:10.7164/antibiotics.54.257