(2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate

Base Information

• Chemical Name: (2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate
• CAS No.: 1214914-17-6
• Molecular Formula: C₁₄H₁₅F₂NO₂
• Molecular Weight: 267.275
• Mol file: 1214914-17-6.mol

Synonyms:(2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate

Chemical Property of (2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate

There total 1 articles about (2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 3-butenoate (1617-18-1) + α,α-difluorobenzeneacetonitrile (2002-72-4) → (2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate (1214914-17-6)

Guidance literature:

ethyl 3-butenoate; With lithium diisopropyl amide; In tetrahydrofuran; at -50 ℃; for 0.5h; Inert atmosphere;

α,α-difluorobenzeneacetonitrile; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.06.001

Reference yield: 48.0%

(2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate (1214914-17-6) + ethyl isocyanate (109-90-0) → 6-(difluoro(phenyl)methyl)-4-(ethoxycarbonylmethyl)-3-ethyl-3,4-dihydropyrimidin-2(1H)-one (1214914-24-5)

Guidance literature:

(2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate; With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃; for 0.5h; Inert atmosphere;

ethyl isocyanate; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.06.001

Reference yield: 46.0%

(2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate (1214914-17-6) + phenyl isocyanate (103-71-9) → 6-(difluoro(phenyl)methyl)-4-(ethoxycarbonylmethyl)-3-phenyl-3,4-dihydropyrimidin-2(1H)-one (1214914-22-3)

Guidance literature:

(2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate; With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃; for 0.5h; Inert atmosphere;

phenyl isocyanate; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.06.001

upstream raw materials:

ethyl 3-butenoate

α,α-difluorobenzeneacetonitrile

Downstream raw materials:

6-(difluoro(phenyl)methyl)-4-(ethoxycarbonylmethyl)-3-phenyl-3,4-dihydropyrimidin-2(1H)-one

6-(difluoro(phenyl)methyl)-4-(ethoxycarbonylmethyl)-3-(2,4,6-trichlorophenyl)-3,4-dihydropyrimidin-2(1H)-one

6-(difluoro(phenyl)methyl)-4-(ethoxycarbonylmethyl)-3-ethyl-3,4-dihydropyrimidin-2(1H)-one