4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester

Base Information

• Chemical Name: 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester
• CAS No.: 201848-59-1
• Molecular Formula: C₁₅H₂₀BrNO₄
• Molecular Weight: 358.232

Synonyms:4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester

Chemical Property of 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester

There total 2 articles about 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromoisobutyric acid bromide (20769-85-1) + methyl 4-hydroxy-3-isopropylaminobenzoate (201848-58-0) → 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester (201848-59-1)

Guidance literature:

With triethylamine; In ethyl acetate; at 0 ℃; for 0.166667h;

DOI:10.1248/cpb.47.22

Reference yield:

methyl 3-amino-4-hydroxybenzoate (536-25-4) → 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester (201848-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / NaHCO₃ / acetonitrile / 5 h / Heating

2: 92 percent / NEt₃ / ethyl acetate / 0.17 h / 0 °C

With sodium hydrogencarbonate; triethylamine; In ethyl acetate; acetonitrile;

DOI:10.1248/cpb.47.22

Reference yield: 81.0%

4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester (201848-59-1) → 3-[(2-bromo-2-methyl-propionyl)-isopropyl-amino]-4-hydroxy-benzoic acid methyl ester (201848-57-9)

Guidance literature:

With formic acid; In di-isopropyl ether; at 50 ℃; for 16h;

DOI:10.1248/cpb.47.22

upstream raw materials:

2-bromoisobutyric acid bromide

methyl 4-hydroxy-3-isopropylaminobenzoate

methyl 3-amino-4-hydroxybenzoate

Downstream raw materials:

methyl 4-isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo<1,4>oxazine-6-carboxylate

3-[(2-bromo-2-methyl-propionyl)-isopropyl-amino]-4-hydroxy-benzoic acid methyl ester

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