{8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester

Base Information

Chemical Name:{8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester
CAS No.:852415-62-4
Molecular Formula:C₃₁H₃₀F₅N₃O₃
Molecular Weight:587.59
Hs Code.:

{8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester

Synonyms:{8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester

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Chemical Property of {8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester

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Technology Process of {8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester

There total 2 articles about {8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 349-65-5
2-Methoxy-5-trifluoromethyl-aniline

: 852415-62-4
{8-fluoro-2-[1-(4-fluoro-3-methylphenyl)piperidine-4-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-3,4-dihydroquinazoline-4-yl}-acetic acid methylester

Guidance literature:: (2E)-3-fluoro-2-({[1-(4-fluoro-3-methyl)piperidine-4-yl]caxbonyl}amino)phenylacrylic acid methylester; With trichlorophosphate; In toluene; at 120 - 125 ℃; for 16h; Heating / reflux;

2-Methoxy-5-trifluoromethyl-aniline; In toluene; for 24h; Heating / reflux;