349-65-5

Usage

Uses

Used in Chemical Synthesis:
2-Methoxy-5-(trifluoromethyl)aniline is used as a synthetic intermediate for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique substitution pattern and reactivity make it a valuable component in the synthesis of complex organic molecules, particularly those with potential applications in the life sciences and materials industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Methoxy-5-(trifluoromethyl)aniline is used as a key building block for the development of novel drug candidates. Its presence in the molecular structure can influence the pharmacokinetic and pharmacodynamic properties of the resulting compounds, potentially leading to improved efficacy and selectivity in targeting specific biological pathways.
Used in Agrochemical Industry:
2-Methoxy-5-(trifluoromethyl)aniline is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its incorporation into these molecules can enhance their performance, providing more effective pest control and crop protection with reduced environmental impact.
Used in Materials Science:
In the field of materials science, 2-Methoxy-5-(trifluoromethyl)aniline can be employed in the development of advanced materials with specific properties, such as improved thermal stability, chemical resistance, or electronic properties. Its unique chemical structure allows for the creation of novel polymers, coatings, and other materials with tailored characteristics for various applications.

InChI:InChI=1/C8H8F3NO/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4H,12H2,1H3

Upstream product

• 394-25-2 2-methoxy-5-nitrobenzotrifluoride 
• 402-10-8 2-bromo-1-methoxy-4-(trifluoromethyl)benzene 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 402-52-8 methyl 4-(trifluoromethyl)phenyl ether 
• 7439-89-6 iron 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 
• 402-44-8 4-Fluorobenzotrifluoride 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 352-32-9 p-fluorotoluene 

Downstream Products

• 324-14-1 acetoacetic acid-(2-methoxy-5-trifluoromethyl-anilide) 
• 402-10-8 2-bromo-1-methoxy-4-(trifluoromethyl)benzene 
• 398-10-7 3-hydroxy-[2]naphthoic acid-(2-methoxy-5-trifluoromethyl-anilide) 
• 53981-95-6 (2-Methoxy-ethyl)-(2-methoxy-5-trifluoromethyl-phenyl)-amine 
• 54010-80-9 (2-Ethoxy-ethyl)-(2-methoxy-5-trifluoromethyl-phenyl)-amine 
• 6064-14-8 1,3-bis(2-methoxy-5-trifluoromethylphenyl)urea 
• 213340-68-2 N-(2-methoxy-5-trifluoromethyl-phenyl)-pivalamide 
• 448895-37-2 NS₁₆₄₃ 
• 16588-75-3 2-methoxy-5-trifluoromethylphenyl isocyanate 
• 160384-28-1 2-methoxy-5-(trifluoromethyl)phenyl carbamoylchloride 
• 284462-89-1 4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline 
• 123-30-8 4-amino-phenol 
• 178974-29-3 4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine 
• 160383-96-0 N-(3,5-dichlorophenyl)-N'-(2-methoxy-5-(trifluoromethyl)phenyl)-urea 

Relevant academic research and scientific papers

Method for preparing 4-bromo-2-methoxy-5-trifluoromethyl benzaldehyde

The invention provides a method for preparing 4-bromo-2-methoxy-5-(trifluoromethyl) benzaldehyde, and belongs to the field of synthesis processes. The method comprises the following steps: carrying out formylation reaction on a compound VI, so as to obtain the 4-bromo-2-methoxy-5-trifluoromethyl benzaldehyde. The method for preparing the 4-bromine-2-methoxy-5-trifluoromethyl benzaldehyde has the advantages of easily available raw materials, mild reaction conditions, simple steps, low cost, safety, no toxicity and easiness in large-scale production, can obviously improve the total yield and purity of the target product 4-bromine-2-methoxy-5-trifluoromethyl benzaldehyde, and has wide application prospects.

Photocatalytic C-H Amination of Aromatics Overcoming Redox Potential Limitations

We report the photocatalytic C-H amination of aromatics overcoming redox potential limitations. Radical cations of aromatic compounds are generated photocatalytically using Ru(phen)3(PF6)2, which has a reduction potential at a high oxidation state (Ered(RuIII/RuII) = +1.37 V vs SCE) lower than the oxidation potentials of aromatic substrates (Eox = +1.65 to +2.27 V vs SCE). The radical cations are trapped with pyridine to give N-arylpyridinium ions, which were converted to aromatic amines.

ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS

The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R' is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R" and R"' are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.

Benzimidazole derivatives, their preparation and pharmaceutical use

A compound having the formula STR1 wherein X is O, SR 4, R 5, R 6 and R 7 independently of each other are hydrogen, halogen, or CF 3 ;R'' is hydrogen or NO 2 ; andfurther a method of treating a disorder or disease of a living animal body, including a huma

Substituted diphenyl ethers

A compound of the formula: STR1 and salts and esters thereof, useful as intermediates for the preparation of compounds of the formula STR2 wherein R1 is an alkyl group optionally substituted by one or more fluorine atoms or by an optionally substituted phenyl group R2 is No2 or Cl and R6 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms.

N-acyl anilines, useful for gastro-enterological disorders

This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof. The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.