2-Propen-1-amine,3-(4-pyridinyl)-(9CI)

Base Information

• Chemical Name: 2-Propen-1-amine,3-(4-pyridinyl)-(9CI)
• CAS No.: 228562-66-1
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.181
• Mol file: 228562-66-1.mol

Synonyms:2-Propen-1-amine,3-(4-pyridinyl)-(9CI)

Chemical Property of 2-Propen-1-amine,3-(4-pyridinyl)-(9CI)

Chemical Property:

• Boiling Point: 283.3±28.0 °C(Predicted)
• PKA: 9.12±0.29(Predicted)
• Density: 1.053±0.06 g/cm3(Predicted)

Purity/Quality:

3-(Pyridin-4-yl)prop-2-en-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propen-1-amine,3-(4-pyridinyl)-(9CI)

There total 3 articles about 2-Propen-1-amine,3-(4-pyridinyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-pyridin-4-yl-allyl)-carbamic acid tert-butyl ester (468060-34-6) → 3-(4-Pyridyl)-2-propenylamine (228562-66-1)

Guidance literature:

With methanol; acetyl chloride; In ethyl acetate; at 20 ℃; for 6h;

DOI:10.1016/S0040-4039(02)00947-4

Reference yield:

4-iodopyridine (15854-87-2) → 3-(4-Pyridyl)-2-propenylamine (228562-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane; H₂O / 18 h / Heating

2: 100 percent / AcCl; MeOH / ethyl acetate / 6 h / 20 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetyl chloride; In 1,2-dimethoxyethane; water; ethyl acetate; 1: Suzuki cross-coupling reaction;

DOI:10.1016/S0040-4039(02)00947-4

Reference yield:

→ 3-(4-Pyridyl)-2-propenylamine (228562-66-1)

Guidance literature:

upstream raw materials:

(3-pyridin-4-yl-allyl)-carbamic acid tert-butyl ester

4-iodopyridine