(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide

Base Information

• Chemical Name: (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide
• CAS No.: 1610840-26-0
• Molecular Formula: C₂₃H₃₅N₃O₅
• Molecular Weight: 433.548

Synonyms:(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide

Chemical Property of (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide

Chemical Property:

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Technology Process of (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide

There total 4 articles about (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate (1196055-80-7) + 4-Aminomethylpiperidine (7144-05-0) → (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide (1610840-26-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2014.04.030

Reference yield:

p-Anisaldehyde dimethyl acetal (2186-92-7) → (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide (1610840-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: camphor-10-sulfonic acid / N,N-dimethyl-formamide / 16 h / 20 °C

2: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C

3: dichloromethane / 16 h / 20 °C

With camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.030

Reference yield:

pantothenic acid (79-83-4) → (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide (1610840-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: camphor-10-sulfonic acid / N,N-dimethyl-formamide / 16 h / 20 °C

2: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C

3: dichloromethane / 16 h / 20 °C

With camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.030

upstream raw materials:

p-Anisaldehyde dimethyl acetal

pantothenic acid

2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate

4-Aminomethylpiperidine

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