2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate

Base Information

• Chemical Name: 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate
• CAS No.: 1196055-80-7
• Molecular Formula: C₂₁H₂₆N₂O₈
• Molecular Weight: 434.446
• Mol file: 1196055-80-7.mol

Synonyms:2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate

Chemical Property of 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate

There total 3 articles about 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-{[(4R)-2-(p-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl]carbonylamino}propionic acid (864239-47-4) + 1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) → 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate (1196055-80-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; for 6h;

DOI:10.1021/ja906537f

Reference yield:

p-Anisaldehyde dimethyl acetal (2186-92-7) → 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate (1196055-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / N,N-dimethyl-formamide / 16 h / 20 °C

2: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C

With camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.030

Reference yield:

pantothenic acid (79-83-4) → 2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate (1196055-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / N,N-dimethyl-formamide / 16 h / 20 °C

2: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C

With camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.030

upstream raw materials:

3-{[(4R)-2-(p-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl]carbonylamino}propionic acid

1-hydroxy-pyrrolidine-2,5-dione

p-Anisaldehyde dimethyl acetal

pantothenic acid

Downstream raw materials:

5'-O-(N-(3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoyl)sulfamoyl)-2',3'-O,N⁽⁴⁾-tribenzoylcytidine

(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(pyridin-3-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide

(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(piperidin-4-ylmethylamino)propyl)-1,3-dioxane-4-carboxamide

(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-oxo-3-(2-(piperazin-1-yl)ethylamino)propyl)-1,3-dioxane-4-carboxamide