(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

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Chemical Name:(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene
CAS No.:847944-45-0
Molecular Formula:C₄₅H₅₃IO₆Si₂
Molecular Weight:872.988
Hs Code.:

(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

Synonyms:(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

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Chemical Property of (2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

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Technology Process of (2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

There total 16 articles about (2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 795290-02-7
(2E,4E,8E,6R,7S)-1-acetoxy-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4,-tetraphenyldisilabutandi-1,4-yl)-α-L-glucopyranosyl]-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

: 847944-45-0
(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at -50 ℃; for 1h;
DOI:10.1002/anie.200460172

Reference yield:

: Acetic acid (2E,4E,8E)-(6R,7S)-7-(tert-butyl-dimethyl-silanyloxy)-9-iodo-2,4,6-trimethyl-nona-2,4,8-trienyl ester

: 847944-45-0
(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 393 mg / TBAF / tetrahydrofuran / 2 h / 20 °C

2.1: 2,6-tert-butyl-4-methyl pyridine / toluene; diethyl ether / 1 h / 20 °C

2.2: Tf₂O / diethyl ether; toluene / 2 h / -80 - -35 °C

3.1: 75 percent / LiEt₃BH / tetrahydrofuran / 1 h / -78 - -50 °C

With 2,6-di-tert-butyl-4-methylpyridine; tetrabutyl ammonium fluoride; lithium triethylborohydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1002/chem.200600462

Reference yield:

: 795289-98-4
phenyl 6-deoxy-4-O-methyl-1-thio-α-L-rhamnopyranoside

: 847944-45-0
(2E,4E,8E,6R,7S)-7-[6-deoxy-4-O-methyl-2,3-O-(1,1,4,4-tetraphenyldisilabutan-1,4-diyl)-α-L-glucopyranosyl]-1-hydroxy-9-iodo-2,4,6-trimethyl-2,4,8-nonatriene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / imidazole / dimethylformamide / 1 h / 0 °C

2.1: 92 percent / mCPBA / CH₂Cl₂ / 2 h / -78 - -20 °C

3.1: 2,6-tert-butyl-4-methyl pyridine / toluene; diethyl ether / 1 h / 20 °C

3.2: Tf₂O / diethyl ether; toluene / 2 h / -80 - -35 °C

4.1: 75 percent / LiEt₃BH / tetrahydrofuran / 1 h / -78 - -50 °C

With 1H-imidazole; 2,6-di-tert-butyl-4-methylpyridine; lithium triethylborohydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.200600462