di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Base Information

• Chemical Name: di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate
• CAS No.: 219591-91-0
• Molecular Formula: C₃₂H₄₃F₂N₃O₈
• Molecular Weight: 635.706
• Mol file: 219591-91-0.mol

Synonyms:di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Chemical Property of di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate

There total 10 articles about di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

bis-(2-fluoro-ethyl)-(4-isocyanato-phenyl)-amine (1027656-77-4) + di-tert-butyl N-<(4-phenoxy)carbonyl>-L-glutamate (180839-19-4) → di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate (219591-91-0)

Guidance literature:

With dibutyltin(II) dilaurate; In toluene; for 12h; Ambient temperature;

DOI:10.1021/jm980425k

Reference yield:

N,N-bis(2-hydroxyethyl)-4-nitroaniline (18226-17-0) → di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate (219591-91-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h

2: Amberlyst 26 F^- / CHCl₃ / 72 h / Heating

3: 84 percent / ammonium formate / 10 percent Pd/C / ethanol / 1.5 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 0.25 h

5: 69 percent / dibutyltin dilaurate / toluene / 12 h / Ambient temperature

With dmap; dibutyltin(II) dilaurate; Amberlyst 26 F^-; ammonium formate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; toluene;

DOI:10.1021/jm980425k

Reference yield:

4-nitrobenzene (219591-97-6) → di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate (219591-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / ammonium formate / 10 percent Pd/C / ethanol / 1.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.25 h

3: 69 percent / dibutyltin dilaurate / toluene / 12 h / Ambient temperature

With dibutyltin(II) dilaurate; ammonium formate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; toluene;

DOI:10.1021/jm980425k

upstream raw materials:

bis-(2-fluoro-ethyl)-(4-isocyanato-phenyl)-amine

di-tert-butyl N-<(4-phenoxy)carbonyl>-L-glutamate

N,N-bis(2-hydroxyethyl)-4-nitroaniline

L-glutamic acid di-tert-butyl ester hydrochloride