3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Base Information

Chemical Name:3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide
CAS No.:1126631-89-7
Molecular Formula:C₂₄H₂₂F₃N₃O₅
Molecular Weight:489.451
Hs Code.:

Synonyms:3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

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Chemical Property of 3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

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Technology Process of 3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

There total 7 articles about 3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 17153-20-7
3-methyl isoxazole-4-carboxylic acid

: 1325762-66-0
1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

: 1126631-89-7
3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: 3-methyl isoxazole-4-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide; In N,N-dimethyl-formamide; at 20 - 40 ℃;

Reference yield:

: 127271-65-2
1-fluoro-4-methoxy-2-(trifluromethyl)benzene

: 1126631-89-7
3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 2.5 h / 20 - 100 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / 2585.81 Torr

3.1: potassium carbonate / dimethyl sulfoxide / 3 h / 120 °C

4.1: hydrogen; ammonia / Raney nickel / methanol / 3 h / 20 °C / 2585.81 Torr

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

7.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

7.2: 20 - 40 °C

With ammonia; hydrogen; sodium hydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1-benzyloxy-4-methoxy-2-trifluoromethyl-benzene

: 1126631-89-7
3-methyl-isoxazole-4-carboxylic acid {1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / 2585.81 Torr

2.1: potassium carbonate / dimethyl sulfoxide / 3 h / 120 °C

3.1: hydrogen; ammonia / Raney nickel / methanol / 3 h / 20 °C / 2585.81 Torr

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 2 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

6.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 20 - 40 °C

With ammonia; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;